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| 發表人 | 討論主題 | 發表時間 | 討論數 |
| 李建達 | 經尿道手術治療前列腺肥大後，以統計分析研究對男性性功能的影響 | 2012/6/28 上午 10:22:38 | 0 |
| 原 文 | 題 目 | The impact of transurethral procedures for benign prostate hyperplasia on male sexual function: a meta-analysis. |
| 作 者 | Zong HT, Peng XX, Yang CC, Zhang Y. | |
| 出 處 | Journal of Andrology 2011, doi: 10.2164/jandrol.111.013490 | |
| 出版日期 | August, 2011. | |
| 評 論 |
在大多數醫院都會使用到經尿道手術來治療男性的前列腺肥大，然而這些方法對男性的性功能會產生什麼衝擊？始終尚無定論。於是本文的作者利用了醫學期刊、實證醫學和Cochrane等資料庫去統計分析比較保守觀察組，經尿道汽化手術(TUEVP)或用鈥(Holmium)鐳射手術(HLT)與經尿道前列腺切除手術(TURP)等各組，分別產生對男性勃起功能(EF)和射精功能(EJF)的影響。 本研究共計12個隨機控制實驗含有1,889個體來分析，結果顯示TURP組比觀察組產生較高的逆行性射精的機會但與TUEVP組或HLT組比較均無明顯差異(p=0.95 & p=0.37)；另外，TURP組比TUEVP組較少產生勃起功能障礙(ED)的機會(p=0.04)；但與HLT組相比，則無明顯差異。 當然，依據本篇的分析上有一些盲點，包括每一篇的研究方法、人數以及評估方式不全相同，故要謹慎考慮各實驗間每個不同病人的差異性。 |
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| abstract | The impact of transurethral procedures for benign prostate hyperplasia (BPH) on male sexual function is still controversial, and we conducted this meta-analysis to compare the effects of different transurethral surgical procedures for the treatment of symptomatic BPH on male erectile function (EF) and ejaculatory function (EJF). Databases including MEDLINE, EMBASE, and the Cochrane Controlled Trial Register were searched to identify randomized controlled trials (RCTs) that compared watchful waiting, transurethral electrovaporization (TUEVP) or holmium laser treatment (HLT) with transurethral resection of the prostate (TURP). Trials were included if they were RCTs, contained fully available data, compared with conventional TURP for BPH, and referred to male EF and EJF. A total of 12 RCTs involving a total of 1889 subjects were ed for analysis, including two trials comparing TURP and watchful waiting, six comparing TURP with TUEVP, and four comparing TURP with HLT. TURP was associated with a higher occurrence of retrograde ejaculation compared to watchful waiting but not to TUEVP (P = 0.95) or HLT (P = 0.37) and associated with a lower incidence of male erectile dysfunction (ED) compared to TUEVP (P = 0.04) but not HLT. According to the analysis, TURP lead to a higher prevalence of retrograde ejaculation compared to watchful waiting but had less of an effect on EF than TUEVP. TURP did not have a significantly different impact on EF or EJF compared to HLT. | |
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