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| 發表人 | 討論主題 | 發表時間 | 討論數 |
| 姜宜妮 | 抗利尿激素對於夜間多尿病人之慢波睡眠的影響 | 2020/8/31 下午 04:00:25 | 0 |
| 原 文 | 題 目 | Rationale, design, and methods of electroencephalography-based investigation of the effects of oral desmopressin on improving slow-wave sleep time in nocturnal polyuria patients (the DISTINCT study): protocol for a single-arm, open-label, single-assignment trial |
| 作 者 | Kazumasa Torimoto* , Makito Miyake, Yasushi Nakai, Katsuya Aoki, Nobumichi Tanaka and Kiyohide Fujimoto | |
| 出 處 | BMC UROLOGY | |
| 出版日期 | August 2020 | |
| 評 論 | 夜間多尿為夜尿患者的重要成因。夜尿會造成患者睡眠中斷、睡眠不足與疲勞，也會增加晚上跌倒和骨折的發生，影響患者的生活品質與健康，目前治療夜尿的藥物以減少夜間尿量的抗利尿激素和放鬆膀胱增加膀胱容量的抗乙醯膽鹼藥物為主，本篇文章探討抗利尿激素對睡眠腦波的影響。本研究共收錄20位65歲以上夜間多尿的病人，夜間多尿定義為睡眠期間尿量佔全日尿量三分之一以上，且在入睡2.5小時內發生第一次不干擾睡眠期。病人於睡前口服50微克抗利尿激素，研究維持四周。觀察對象為慢波睡眠的平均時間。經由本研究之設計，可觀察到移動式腦波儀的觀察點和在夜尿與睡眠腦波的關聯。 | |
| abstract |
Background: Nocturia is one of the most bothersome lower urinary tract symptoms and often impairs sleep quality in the elderly. Although previous studies on nocturia have indicated that the successful treatment of nocturia improves sleep quality, most used questionnaires and activity devices to analyze sleep/wake patterns.Therefore, there is little information about the treatment effects of desmopressin on objective sleep quality. The aim of the DISTINCT study is to investigate the change in subjective and objective sleep quality usingelectroencephalography (EEG) and the Pittsburgh Sleep Quality Index (PSQI) after the administration of desmopressin in patients with nocturia due to nocturnal polyuria. Methods: A total of 20 male patients, ≥65 years old, with nocturnal polyuria, defined as a nocturnal polyuria index (NPi) (nocturnal urine volume / 24 h urine volume) value ≥0.33, will participate in this study. The participants must have a nocturnal frequency of ≥2 and the first uninterrupted sleep period (FUSP) must occur within < 2.5 h. Desmopressin 50 μg per day will be orally administered before going to bed for 4 weeks. Urinary frequency volume charts (FVC) and EEG will be recorded prior to treatment and at 1 week and 4 weeks after the initiation of treatment. The PSQI will be completed before and 4 weeks after treatment. The primary endpoint is the change from baseline in the mean time of slow-wave sleep (sleep stages N3 and N4) at 4 weeks. The secondary endpoints include the change in the mean value of each sleep variable, the mean delta power during the FUSP, the correlation between nocturnal urinary frequency and slow-wave sleep time, and the change in PSQI score before and after treatment. Discussion: The DISTINCT study will provide valuable evidence to indicate that oral desmopressin treatment for nocturnal polyuria prolongs the FUSP, resulting in the extension of slow-wave sleep time associated with sleep quality. Trial registration: The Japan Registry of Clinical Trials (jRCTs051190080). Registered 9 December, 2019. Keywords: Nocturia, Nocturnal polyuria, Desmopressin, Sleep quality, Slow-wave |
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