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林于巧 衰弱症的高齡患者在進行吊帶手術後有較高的併發症風險及重複手術之機率 2022/8/3 下午 07:34:36 0
原 文 題  目 Frailty Is Associated with an Increased Risk of Complications and Need for Repeat Procedures after Sling Surgery in Older Adults
作  者 Michelle E. Van Kuiken, Shoujun Zhao, Kenneth Covinsky, John Boscardin, Emily Finlayson, and Anne M. Suskind
出  處 The Journal of Urology 207.6 (2022): 1276-1284.
出版日期 2022 Jun 1
評 論 吊帶手術是應力型尿失禁的女性患者的標準治療,目前的研究資料顯示吊帶手術對於年輕或中年女性患者是非常有效,但在高齡且具有衰弱症的女性患者是否適用答案仍未明朗。

本篇研究是針對於2014至2016年間接受吊帶手術的54112位65歲以上高齡患者,將患者分為「無衰弱症」、「衰弱症前期」、「輕度衰弱症」、「中重度衰弱症」後統計手術後併發症、手術一年內死亡率以及手術後一年內因持續尿失禁或尿滯留需再次手術的機率。統計結果發現中重度衰弱症的患者和無衰弱症的患者相比,具有較高機率的術後30天內併發症、手術一年內死亡率及一年內再次手術機率。

因此本篇作者認為,因衰弱症患者會於手術的併發症機率有顯著影響,手術前應評估高齡患者衰弱症的研究程度,以及考慮在手術前先行治療衰弱症。
abstract

Purpose:
Sling surgery is the gold standard treatment for stress urinary incontinence in women. While data support the use of sling surgery in younger and middle-aged women, outcomes in older, frail women are largely unknown.

Materials and Methods:
Data were examined for all Medicare beneficiaries ≥65 years old who underwent sling surgery with or without concomitant prolapse repair from 2014 to 2016. Beneficiaries were stratified using the Claims-Based Frailty Index (CFI) into 4 categories: not frail (CFI <0.15), prefrail (0.15 ≤CFI <0.25), mildly frail (0.25 ≤CFI <0.35) and moderately to severely frail (CFI ≥0.35). Outcomes included rates and relative risk of 30-day complications, 1-year mortality and repeat procedures for persistent incontinence or obstructed voiding at 1 year.

Results:
A total of 54,112 women underwent sling surgery during the study period, 5.2% of whom were mildly to moderately to severely frail. Compared to the not frail group, moderately to severely frail beneficiaries demonstrated an increased adjusted relative risk (aRR) of 30-day complications (56.5%; aRR 2.5, 95% CI: 2.2–2.9) and 1-year mortality (10.5%; aRR 6.7, 95% CI: 4.0–11.2). Additionally, there were higher rates of repeat procedures in mildly to severely frail beneficiaries (6.6%; aRR 1.4, 95% CI: 1.2–1.6) compared to beneficiaries who were not frail.

Conclusions:
As frailty increased, there was an increased relative risk of 30-day complications, 1-year mortality and need for repeat procedures for persistent incontinence or obstructed voiding at 1 year. While there were fewer sling surgeries in performed frail women, the observed increase in complication rates was significant. Frailty should be strongly considered before pursuing sling surgery in older women.

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